GLP-1 medications, including semaglutide and tirzepatide, are known to slow digestion as part of their mechanism of action. This can result in side effects like constipation. Proper management through lifestyle and dietary changes, may help with symptom management.
Addressing constipation
Constipation is a common side effect of GLP-1 medications. Below are lifestyle tips that may help with symptom management:
1. Stay hydrated:
Aim to drink plenty of water each day—ideally around 100 ounces (~3 liters), adjusted for individual needs.
Adding electrolytes to your water may further support hydration.
2. Increase dietary fiber:
Incorporate high-fiber foods into your diet, such as: - Fruits like apples and bananas - Whole grains like oatmeal - Cooked vegetables
Gradual changes are recommended to avoid cramping or bloating.
3. Engage in light physical activity:
Regular gentle activities, such as daily walks, can stimulate bowel movements.
When to seek medical attention
While most cases of GLP-1 medication-related constipation can be resolved with the above strategies, certain symptoms may indicate a more serious condition requiring medical evaluation:
No bowel movement for 3-5 days or more despite attempting self-care.
Severe abdominal pain or cramping.
Persistent vomiting.
Inability to pass gas
Marked or worsening abdominal bloating or distention
Blood in the stool or black, tarry stool
Fever
Signs of dehydration, such as dizziness, lightheadedness, or fainting
Do not wait to seek medical attention if symptoms are escalating or causing significant discomfort, even if it has been fewer than 3 days.
Situations requiring emergency care
If you experience any of the above symptoms combined with significant discomfort, visit an urgent care clinic or emergency room without delay.
If you have any concerns, visit https://portal.tryshed.com/support and message "Talk to a nurse". The clinical team is always here to support you.
The information above is for general informational purposes only and is not intended to be medical advice. Always follow the guidance and instructions provided by your prescribing clinician.