Common side effects of GLP-1 medications
GLP-1 (glucagon-like peptide-1) therapies, including semaglutide (GLP-1 receptor agonist) and tirzepatide (GLP-1 + GIP receptor agonist), are powerful tools for supporting weight management and blood sugar control. While most people tolerate them well, side effects can occur—especially when first starting or adjusting your dose.
At Shed, your well-being comes first. Licensed providers partnered with Shed are available to support you and address any concerns you may have.
What you might experience
Note: Side effects vary from person to person. Most are mild and temporary. Always talk to your provider if you have concerns.
Nausea
One of the most common side effects, often temporary and improving as your body adjusts.Vomiting
Can occur, especially after a dose increase. Staying hydrated and eating small, bland meals may help.Diarrhea
Some patients notice looser stools while their digestive system adapts.Constipation
A frequent digestive change. Drinking water, adding fiber, and staying active can help.Decreased Appetite
A primary goal of GLP-1 medications—just be sure to maintain a balanced, nutrient-rich diet.Abdominal Discomfort or Bloating
May be related to delayed gastric emptying, which can cause a sensation of prolonged fullness.Fatigue
Some patients report feeling more tired than usual during dose adjustments.Headache
Generally mild and often improves over time.Indigestion
Can show up as heartburn, stomach upset, or slower digestion.Injection Site Reactions
Redness, swelling, or mild discomfort at the injection site are possible but usually short-lived.
What to Know:
Gastrointestinal (GI) side effects—like nausea, vomiting, and bloating—are the most common and are typically dose-related. This means they often appear or worsen after a dose increase but tend to settle as your body adjusts over time.
Some patients also experience delayed gastric emptying, which can lead to a sensation of prolonged fullness or bloating. You might not immediately recognize it as a side effect, but if you’re feeling unusually full for hours after eating or noticing slower digestion, this could be why.
Serious but Rare Complications:
While uncommon, serious potential complications associated with GLP-1 medications include pancreatitis, gallbladder problems, and elevations in kidney function tests. Patients should promptly report severe abdominal pain, jaundice, significant changes in urination, or swelling to their healthcare provider.
How Shed supports you
Every person responds differently to GLP-1 medications. Shed offers:
Unlimited provider visits – Connect with a licensed provider by scheduling an appointment through your portal anytime you need guidance.
Symptom management – From adjusting your dose to prescribing anti-nausea medications, licensed providers partnered with Shed are here to help.
Tailored advice – Get recommendations based on your specific side effects and treatment plan.
Need help or have questions?
You can reach out anytime through the Shed portal or schedule a virtual visit with one of the licensed providers. We’re here to ensure you stay safe, comfortable, and on track with your treatment.
https://portal.tryshed.com/
If you are experiencing side effects, visit https://portal.tryshed.com/support and message "Talk to a nurse". The clinical team is always here to support you.
Compounded medications are prepared by licensed pharmacies to meet individual patient needs. While they are not reviewed or approved by the FDA for safety or effectiveness, they are made in accordance with strict regulatory guidelines. Prescription is only available after consultation with a licensed provider to determine if treatment is appropriate.